NS3 GT6
Download full data set for GT6
Asunaprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Comments |
| WT (6a_EUHK2) | 0.9 | 1x | likely susceptible | | 1 | |
| V36M | | | | | | |
| V36A | | | | | | |
| V36I | | | | | | |
| V36L | | | | | | |
| Q41K | | | | | | |
| Q41R | | | | | | |
| F43S | | | | | | |
| T54A | | | | | | |
| V55A | | | | | | |
| Y56H | | | | | | |
| Y56F | | | | | | |
| L80H | | | | | | |
| L80I | | | | | | |
| L80K | | | | | | |
| L80L | | | | | | |
| L80Q | | | | | | |
| L80M | | | | | | |
| L80R | | | | | | |
| V107I | | | | | | |
| S122A | | | | | | |
| S122D | | | | | | |
| S122G | | | | | | |
| S122N | | | | | | |
| S122R | | | | | | |
| S122T | | | | | | |
| I132L | | | | | | |
| S133R | | | | | | |
| K136R | | | | | | |
| R155K | | | | | | |
| R155G | | | | | | |
| R155T | | | | | | |
| R155W | | | | | | |
| A156G | | | | | | |
| A156M | | | | | | |
| A156S | | | | | | |
| A156T | | | | | | |
| A156V | | | | | | |
| V158I | | | | | | |
| A166S | | | | | | |
| D168A | | | | | | |
| D168C | | | | | | |
| D168E | | | | | | |
| D168F | | | | | | |
| D168G | | | | | | |
| D168H | | | | | | |
| D168I | | | | | | |
| D168K | | | | | | |
| D168L | | | | | | |
| D168N | | | | | | |
| D168T | | | | | | |
| D168V | | | | | | |
| D168Y | | | | | | |
| I170A | | | | | | |
| I170T | | | | | | |
| I170V | | | | | | |
| M179T | | | | | | |
| V36A+D168A | | | | | | |
| V36A+Q41R | | | | | | |
| V36M+R155K | | | | | | |
| Q41R+S122N | | | | | | |
| Q41R+D168A | | | | | | |
| Q41R+D168Y | | | | | | |
| Q41R+D168H | | | | | | |
| Y56H+D168E | | | | | | |
| Y56H+D168A | | | | | | |
| Y56H+D168V | | | | | | |
| Y56H+D168Any | | | | | | |
| K80Q+S122T | | | | | | |
| L80K+D168E | | | | | | |
| S122N+D168A | | | | | | |
| D168H+M179T | | | | | | |
| D168V+M179T | | | | | | |
| D168Y+M179T | | | | | | |
| V55A+L80K+S122N | | | | | | |
| 1. Sunvepra Canadian Prodcut Monograph 2016 |
Glecaprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Comments |
| WT (6a_EUHK2) | 0.86 | 1x | likely susceptible | | 1 | clinical isolate=0.3 (0.05-3.8) |
| V36M | | | | | | |
| V36A | | | | | | |
| V36I | | | | | | |
| V36L | | | | | | |
| Q41K | | | | | | |
| Q41R | | | | | | |
| F43S | | | | | | |
| T54A | | | | | | |
| V55A | | | | | | |
| Y56H | | | | | | |
| Y56F | | | | | | |
| L80H | | | | | | |
| L80I | | | | | | |
| L80K | | | | | | |
| L80L | | | | | | |
| L80Q | | | | | | |
| L80M | | | | | | |
| L80R | | 21x | resistance likely | | 1 | |
| V107I | | | | | | |
| S122A | | | | | | |
| S122D | | | | | | |
| S122G | | | | | | |
| S122N | | | | | | |
| S122R | | | | | | |
| S122T | | | | | | |
| I132L | | | | | | |
| S133R | | | | | | |
| K136R | | | | | | |
| R155K | | | | | | |
| R155G | | | | | | |
| R155T | | | | | | |
| R155W | | | | | | |
| A156G | | January 1, 1970 | | | | |
| A156M | | January 1, 1970 | resistance possible | yes | 2 | |
| A156S | | | | | | |
| A156T | | | | | | |
| A156V | | | | | | |
| V158I | | | | | | |
| A166S | | | | | | |
| D168A | 12.2 | 81x | resistance likely | | 1 | |
| D168C | | | | | | |
| D168E | | | | | | |
| D168F | | | | | | |
| D168G | 28.6 | 191x | resistance likely | | 1 | |
| D168H | 22 | 146x | resistance likely | | 1 | |
| D168I | | | | | | |
| D168K | | | | | | |
| D168L | | | | | | |
| D168N | | | | | | |
| D168T | | | | | | |
| D168V | 5.8 | 38x | resistance likely | | 1 | |
| D168Y | 16.3 | 109x | resistance likely | | 1 | |
| I170A | | | | | | |
| I170T | | | | | | |
| I170V | | | | | | |
| M179T | 0.19 | 1.3x | likely susceptible | | 1 | |
| V36A+D168A | | | | | | |
| V36A+Q41R | | | | | | |
| V36M+R155K | | | | | | |
| Q41R+S122N | | | | | | |
| Q41R+D168A | | | | | | |
| Q41R+D168Y | | | | | | |
| Q41R+D168H | | | | | | |
| Y56H+D168E | | | | | | |
| Y56H+D168A | | | | | | |
| Y56H+D168V | | | | | | |
| Y56H+D168Any | | | | | | |
| K80Q+S122T | | | | | | |
| L80K+D168E | | | | | | |
| S122N+D168A | | | | | | |
| D168H+M179T | 22.9 | 153x | resistance likely | | 1 | |
| D168V+M179T | 8.2 | 54x | resistance likely | | 1 | |
| D168Y+M179T | 14.4 | 96x | resistance likely | | 1 | |
| V55A+L80K+S122N | | >30x | resistance likely | | 1 | |
| 1. FDA Microbiology Review https://www.accessdata.fda.gov/drugsatfda_docs/nda/2017/209394Orig1s000MicroR.pdf |
| 2. Asselah T, et al. 2018. Journal of Hepatology 68: S39 |
Grazoprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Comments |
| WT (6a_EUHK2) | 0.9 | 1x | likely susceptible | | 1 | |
| V36M | | | | | | |
| V36A | | | | | | |
| V36I | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| V36L | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| Q41K | | | | | | |
| Q41R | | | | | | |
| F43S | | | | | | |
| T54A | | | | | | |
| V55A | | | | | | |
| Y56H | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| Y56F | | | | | | |
| L80H | | | | | | |
| L80I | | | | | | |
| L80K | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| L80L | | | | | | |
| L80Q | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| L80M | | | | | | |
| L80R | | | | | | |
| V107I | | | | | | |
| S122A | | | | | | |
| S122D | | | | | | |
| S122G | | | | | | |
| S122N | | | | | | |
| S122R | | | | | | |
| S122T | | | | | | |
| I132L | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| S133R | | | | | | |
| K136R | | | | | | |
| R155K | | | | | | |
| R155G | | | | | | |
| R155T | | | | | | |
| R155W | | | | | | |
| A156G | | | | | | |
| A156M | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| A156S | | | | | | |
| A156T | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| A156V | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| V158I | | | | | | |
| A166S | | | | | | |
| D168A | | | | | | |
| D168C | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| D168E | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| D168F | | | | | | |
| D168G | | | | | | |
| D168H | | | | | | |
| D168I | | | | | | |
| D168K | | | | | | |
| D168L | | | | | | |
| D168N | | | | | | |
| D168T | | | | | | |
| D168V | | | | | | |
| D168Y | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| I170A | | | | | | |
| I170T | | | | | | |
| I170V | | | resistance possible | Yes | 2 | Clincial VF RAV (2) |
| M179T | | | | | | |
| V36A+D168A | | | | | | |
| V36A+Q41R | | | | | | |
| V36M+R155K | | | | | | |
| Q41R+S122N | | | | | | |
| Q41R+D168A | | | | | | |
| Q41R+D168Y | | | | | | |
| Q41R+D168H | | | | | | |
| Y56H+D168E | | | | | | |
| Y56H+D168A | | | | | | |
| Y56H+D168V | | | | | | |
| Y56H+D168Any | | | | | | |
| K80Q+S122T | | | | | | |
| L80K+D168E | | | | | | |
| S122N+D168A | | | | | | |
| D168H+M179T | | | | | | |
| D168V+M179T | | | | | | |
| D168Y+M179T | | | | | | |
| V55A+L80K+S122N | | | | | | |
| 1. Lahser et al (2016) AAC doi: 10.1128/AAC.00051-16 |
| 2. FDA Microbiology/Virology Reviews Zepatier_208261Orit1s000 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000MicroR.pdf |
Paritaprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Comments |
| WT (6a_EUHK2) | 0.68 | 1x | likely susceptible | | 1 | |
| V36M | | | | | | |
| V36A | | | | | | |
| V36I | | | | | | |
| V36L | | | | | | |
| Q41K | | | | | | |
| Q41R | | | | | | |
| F43S | | | | | | |
| T54A | | | | | | |
| V55A | | | | | | |
| Y56H | | | | | | |
| Y56F | | | | | | |
| L80H | | | | | | |
| L80I | | | | | | |
| L80K | | | | | | |
| L80L | | | | | | |
| L80Q | | | | | | |
| L80M | | | | | | |
| L80R | | | | | | |
| V107I | | | | | | |
| S122A | | | | | | |
| S122D | | | | | | |
| S122G | | | | | | |
| S122N | | | | | | |
| S122R | | | | | | |
| S122T | | | | | | |
| I132L | | | | | | |
| S133R | | | | | | |
| K136R | | | | | | |
| R155K | | | | | | |
| R155G | | | | | | |
| R155T | | | | | | |
| R155W | | | | | | |
| A156G | | | | | | |
| A156M | | | | | | |
| A156S | | | | | | |
| A156T | | | | | | |
| A156V | | | | | | |
| V158I | | | | | | |
| A166S | | | | | | |
| D168A | | | | | | |
| D168C | | | | | | |
| D168E | | | | | | |
| D168F | | | | | | |
| D168G | | | | | | |
| D168H | | | | | | |
| D168I | | | | | | |
| D168K | | | | | | |
| D168L | | | | | | |
| D168N | | | | | | |
| D168T | | | | | | |
| D168V | | | | | | |
| D168Y | | | | | | |
| I170A | | | | | | |
| I170T | | | | | | |
| I170V | | | | | | |
| M179T | | | | | | |
| V36A+D168A | | | | | | |
| V36A+Q41R | | | | | | |
| V36M+R155K | | | | | | |
| Q41R+S122N | | | | | | |
| Q41R+D168A | | | | | | |
| Q41R+D168Y | | | | | | |
| Q41R+D168H | | | | | | |
| Y56H+D168E | | | | | | |
| Y56H+D168A | | | | | | |
| Y56H+D168V | | | | | | |
| Y56H+D168Any | | | | | | |
| K80Q+S122T | | | | | | |
| L80K+D168E | | | | | | |
| S122N+D168A | | | | | | |
| D168H+M179T | | | | | | |
| D168V+M179T | | | | | | |
| D168Y+M179T | | | | | | |
| V55A+L80K+S122N | | | | | | |
| 1. Viekira Pak US Product Label jan 28, 2016 |
Simeprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Comments |
| WT (6a_EUHK2) | | | | | | |
| V36M | | | | | | |
| V36A | | | | | | |
| V36I | | | | | | |
| V36L | | | | | | |
| Q41K | | | | | | |
| Q41R | | | | | | |
| F43S | | | | | | |
| T54A | | | | | | |
| V55A | | | | | | |
| Y56H | | | | | | |
| Y56F | | | | | | |
| L80H | | | | | | |
| L80I | | | | | | |
| L80K | | | | | | |
| L80L | | | | | | |
| L80Q | | | | | | |
| L80M | | | | | | |
| L80R | | | | | | |
| V107I | | | | | | |
| S122A | | | | | | |
| S122D | | | | | | |
| S122G | | | | | | |
| S122N | | | | | | |
| S122R | | | | | | |
| S122T | | | | | | |
| I132L | | | | | | |
| S133R | | | | | | |
| K136R | | | | | | |
| R155K | | | | | | |
| R155G | | | | | | |
| R155T | | | | | | |
| R155W | | | | | | |
| A156G | | January 1, 1970 | | | | |
| A156M | | January 1, 1970 | | | | |
| A156S | | | | | | |
| A156T | | | | | | |
| A156V | | | | | | |
| V158I | | | | | | |
| A166S | | | | | | |
| D168A | | | | | | |
| D168C | | | | | | |
| D168E | | | | | | |
| D168F | | | | | | |
| D168G | | | | | | |
| D168H | | | | | | |
| D168I | | | | | | |
| D168K | | | | | | |
| D168L | | | | | | |
| D168N | | | | | | |
| D168T | | | | | | |
| D168V | | | | | | |
| D168Y | | | | | | |
| I170A | | | | | | |
| I170T | | | | | | |
| I170V | | | | | | |
| M179T | | | | | | |
| V36A+D168A | | | | | | |
| V36A+Q41R | | | | | | |
| V36M+R155K | | | | | | |
| Q41R+S122N | | | | | | |
| Q41R+D168A | | | | | | |
| Q41R+D168Y | | | | | | |
| Q41R+D168H | | | | | | |
| Y56H+D168E | | | | | | |
| Y56H+D168A | | | | | | |
| Y56H+D168V | | | | | | |
| Y56H+D168Any | | | | | | |
| K80Q+S122T | | | | | | |
| L80K+D168E | | | | | | |
| S122N+D168A | | | | | | |
| D168H+M179T | | | | | | |
| D168V+M179T | | | | | | |
| D168Y+M179T | | | | | | |
| V55A+L80K+S122N | | | | | | |
| 1. Jensen et al. 2015. AAC 59(12):7426-36 |
Voxilaprevir
| Mutation | EC50 (nM) | Fold-shift | Phenotype | Clinical RAS | Reference | Replication Capacity (%WT) | Comments |
| WT (6a_EUHK2) | 1.26 (SD 1.87) | 1x | likely susceptible | | 2 | 100 (3) | |
| V36M | | | | | | | |
| V36A | | | likely susceptible | | 2 | | |
| V36I | | | | | | | |
| V36L | | | | | | | |
| Q41K | | 2.5-20x | resistance possible | | 2 | | |
| Q41R | | 2.7x | resistance possible | | 3,2,1 | 195 (3) | |
| F43S | | | | | | | |
| T54A | | | | | | | |
| V55A | | | likely susceptible | | 2 | | |
| Y56H | | 2.5-20x | resistance possible | | 2,1 | | |
| Y56F | | | | | | | |
| L80H | unfit | | | | 2 | | K80H |
| L80I | | | | | | | |
| L80K | | 0.5x | likely susceptible | | 3,2 | 57.3 (3) | |
| L80L | | | likely susceptible | | 2 | | |
| L80Q | | | likely susceptible | | 2,3 | | |
| L80M | | | | | | | |
| L80R | | | likely susceptible | | 2 | | |
| V107I | | | | | | | |
| S122A | | | likely susceptible | | 2 | | |
| S122D | | | likely susceptible | | 2 | | |
| S122G | | | likely susceptible | | 2 | | |
| S122N | | | likely susceptible | | 2 | | |
| S122R | | | | | | | |
| S122T | | | likely susceptible | | 2,3 | | |
| I132L | | | | | | | |
| S133R | | <2x | likely susceptible | | 3 | | |
| K136R | | <2x | likely susceptible | | 3 | | |
| R155K | | | | | | | |
| R155G | unfit | | | | 2 | | |
| R155T | | | | | | | |
| R155W | unfit | | | | 2,1 | | |
| A156G | | | | | 1 | | VOX RAs >2.5x (1) |
| A156M | | | | | | | |
| A156S | | | | | 1 | | VOX RAs >2.5x (1) |
| A156T | unfit | | | | 2,1 | | VOX RAs >2.5x (1) |
| A156V | unfit | | | | 2,1 | | VOX RAs >2.5x (1) |
| V158I | | | | | | | |
| A166S | unfit | | | | 2,1 | | |
| D168A | | 2.5-20x | resistance possible | | 2,1 | | |
| D168C | | | | | | | |
| D168E | | 6x | resistance possible | | 3,2 | | |
| D168F | | | | | | | |
| D168G | | | | | | | |
| D168H | | 4.2x | resistance possible | | 3,2,1 | 19.4 (3) | |
| D168I | | | | | | | |
| D168K | unfit | | | | 2 | | |
| D168L | | | | | | | |
| D168N | | | | | | | |
| D168T | | | | | | | |
| D168V | | | likely susceptible | | 2 | | |
| D168Y | | 1.5x | likely susceptible | | 2 | 16.4 (3) | |
| I170A | | | | | | | |
| I170T | | | | | | | |
| I170V | | | likely susceptible | | 2,3 | | |
| M179T | | | | | | | |
| V36A+D168A | | 2.5-20x | resistance possible | | 2 | | |
| V36A+Q41R | | 2.5-20x | resistance possible | | 2 | | |
| V36M+R155K | | | | | | | |
| Q41R+S122N | | | likely susceptible | | 2 | | |
| Q41R+D168A | | 2.5-20x | resistance possible | | 2 | | |
| Q41R+D168Y | | 17.5x | resistance likely | | 2 | 98.8 (3) | |
| Q41R+D168H | | 39x | resistance likely | | 3,2 | 92.3 (3) | |
| Y56H+D168E | | 20-100x | resistance likely | | 2,3 | | |
| Y56H+D168A | | | | | | | |
| Y56H+D168V | | | | | | | |
| Y56H+D168Any | | | | | | | |
| K80Q+S122T | | | likely susceptible | | 2 | | |
| L80K+D168E | | 1.1x | likely susceptible | | 2 | | |
| S122N+D168A | | 2.5-20x | resistance possible | | 2 | | |
| D168H+M179T | | | | | | | |
| D168V+M179T | | | | | | | |
| D168Y+M179T | | | | | | | |
| V55A+L80K+S122N | | 2x | likely susceptible | | 2 | | |
| 1. Sarrazin C, et al. 2017. Gastroenterology 152: S1062 |
| 2. Dvory-Sobol H et al 2017 AASLD. http://www.natap.org/2017/AASLD/AASLD_29.htm |
| 3. FDA Vosevi Microbiology Reviews 209195Orig1s000MicroR |
