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Genotype 1b NS5A RAS

 Daclastasvirin GT1bLedipasvirin GT1bVelpatasvirin GT1bOmbitasvirin GT1bPibrentasvirin GT1bElbasvirin GT1b
MutationEC50 Fold-shift/Clinical RASPhenotypeEC50 Fold-shift/Clinical RASPhenotypeEC50 Fold-shift/Clinical RASPhenotypeEC50 Fold-shift/Clinical RASPhenotypeEC50 Fold-shift/Clinical RASPhenotypeEC50 Fold-shift/Clinical RASPhenotype
WT (1b_con1)1xlikely susceptible1xlikely susceptible1likely susceptible1xlikely susceptible1xlikely susceptible1xlikely susceptible
Q24K<2.5xlikely susceptible<2.5xlikely susceptible2.5 - 100xresistance possible
Q24R
L28AcRAS/cRASresistance possible
L28M1.3x/cRAS/cRASresistance possible<2.5x/cRASresistance possible0.7xlikely susceptible2x/cRASresistance possible1x/cRASresistance possible2x/cRASresistance possible
L28TcRAS/cRASresistance possible661xresistance likely0.9xlikely susceptible
L28I3xlikely susceptible
L28V2.3xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible1.3xlikely susceptible
P29ScRAS/cRASresistance possible
P29del1,666,666x/cRAS/cRASresistance likely361139xresistance likely10xresistance possible
R30G100x/cRAS/cRASresistance likely<10xlikely susceptible
R30H6.7x/cRAS/cRASresistance possible<2.5xlikely susceptible<2.5xlikely susceptible<10xlikely susceptible
R30K1x/cRAS/cRASresistance possible<2.5xlikely susceptible<2.5xlikely susceptible
R30L0.3xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
R30Plikely susceptible<10xlikely susceptible
R30Q0.7x/cRAS/cRASresistance possible<2.5xlikely susceptible<2.5xlikely susceptible0.4x/cRASresistance possible0.5x/cRASresistance possible3x/cRASresistance likely
R30Slikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
R30T<2.5xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
L31F5x/cRAS/cRASresistance possible2xlikely susceptible0.7xlikely susceptible10x/cRASresistance possible1.2xlikely susceptible15x/cRASresistance likely
L31I3x/cRAS/cRASresistance possible10-50x/cRASresistance possible3.8xresistance possible2xlikely susceptible
L31KcRASresistance possible
L31M3x/cRAS/cRASresistance possible3x/cRASresistance possible1.7x/cRASresistance possible0.9x/cRASresistance possible1.4-1.5xlikely susceptible7x/cRASresistance likely
L31T<10xlikely susceptible
L31V28x/cRAS/cRASresistance likely10-50x/cRASresistance possible2x/cRASresistance possible8X/cRASresistance possible0.8xlikely susceptible13x/cRASresistance likely
L31W91xresistance possible
P32F
P32L16xlikely susceptible<2.5xlikely susceptible
P32KcRASresistance possible
P32RcRASresistance possible
P32NcRASresistance possible
P32KcRASresistance possible
P32TcRAS/cRAS2.5-10xlikely susceptible>2.5xcRASresistance possible
P32S
P32del>1,666,667x/cRAS/cRASresistance likely1036x/cRASresistance likely
F37L1xlikely susceptible
Q54H1x/cRAS/cRASresistance possible<2.5xlikely susceptible1xlikely susceptible1.1xlikely susceptible
Q54N1xlikely susceptible
Q54L0.3xlikely susceptible
Q54Y1.3xlikely susceptible/cRASresistance possible1.2xlikely susceptible
P58A0.7xlikely susceptible
P58D100-1000xresistance likely<2.5xlikely susceptible>2.5x
P58L1x/cRAS/cRASresistance possible
P58Q<2.5xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
P58R<2.5xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
P58S1x/cRAS/cRASresistance possible<2.5xlikely susceptible<2.5xlikely susceptible0.8x/cRASresistance possible1.3xlikely susceptible/cRASresistance possible
P58T1xlikely susceptible<2.5xlikely susceptible2.5 - 100xresistance possible0.4xlikely susceptible
Q62Dlikely susceptible
Q62E1x/cRAS/cRASresistance possible2.3xlikely susceptible
Q62A0.7xlikely susceptible
Q62H1xlikely susceptible
Q62N0.7xlikely susceptible
Q62R1xlikely susceptible
Q62S1xlikely susceptible
A92E1.3x/cRAS/cRASresistance possible<2.5xlikely susceptible<2.5xlikely susceptible0.7xlikely susceptible0.5xlikely susceptible
A92V
A92K>100x/cRAS/cRASresistance likely>1000xresistance likely>100xresistance likely
A92P<2.5xlikely susceptible<2.5xlikely susceptible
A92T1xlikely susceptible<2.5x/cRASresistance possible<2.5xlikely susceptible
A92V0.3xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible0.5xlikely susceptible
Y93C3xlikely susceptible/cRASresistance possible0.2x/cRASresistance possible1.7xlikely susceptible
Y93H30x/cRAS/cRASresistance likely1325x/cRASresistance likely3x/cRASresistance likely77x/cRASresistance likely0.6xlikely susceptible67x/cRASresistance likely
Y93N50xresistance possible>100xresistance likely3x/cRASresistance likely202xresistance likely0.6xlikely susceptible
Y93F0.7xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
Y93L<2.5xlikely susceptible<2.5xlikely susceptible<2.5xlikely susceptible
Y93R>2.5 - 100xresistance possible
Y93T2.5 - 100xresistance possible
Y93S6.7x<100xresistance possible0.6x/cRASresistance possible12x/cRASresistance possible0.4xlikely susceptible
V121I0.2xlikely susceptible
D320E0.9xlikely susceptible
L23F+L31F13xlikely susceptible
Q24R+R30Q<2.5xlikely susceptible<2.5xlikely susceptible
L28I+R30Q6.7xlikely susceptible
L28M+L31F569Xresistance likely
L28M+P32del6326xresistance likely
L28M+R30L1xlikely susceptible
L28M+R30Q1xlikely susceptible0.4xlikely susceptible
L28M+R30Q0.5x/cRASresistance possible0.4x
L28M+Y93H1000x/cRAS/cRASresistance likely>100xresistance likely5xresistance possible415xresistance likely1.2xlikely susceptible
L28V+L31F2170Xresistance likely
L28V+R30Q0.3xlikely susceptible
R30H+Y93H2,667xresistance likely
R30L+L31M3xlikely susceptible
R30Q+L31M16.7xlikely susceptible<2.5xlikely susceptible
R30Q+L31F88xresistance possible
R30Q+L31V<2.5xlikely susceptible
R30Q+Q54H0.3xlikely susceptible
R30Q+A92K77,000xresistance likely
R30Q+Y93H200xresistance likely>100xresistance likely<2.5xlikely susceptible284xresistance likely1.2xlikely susceptible
R30Q+Y93S23.3resistance possible
L31F+A92E1022xresistance likely0.6xlikely susceptible
L31F+P32del1,666,667xresistance likely
L31F+P58L78xresistance possible
L31F+Q54H2.4xlikely susceptible
L31F+Y93H5000xresistance likely27resistance likely415,1027xresistance likely1.5xlikely susceptible
L31IV+Y93H33,677x/cRAS/cRASresistance likely
L31I+A92V1xlikely susceptible
L31I+Y93H2492x/cRAS/cRASresistance likely>100xresistance likely
L31M+A92K1,281,333xresistance likely
L31M+P58L200x/cRAS/cRASresistance likely
L31M+P58S30xresistance possible
L31M+Q54H1.3xlikely susceptible
L31M+Y93C>100xresistance likely
L31M+Y93H7105x/cRAS/cRASresistance likely20270xresistance likely44xresistance likely142xresistance likely0.7xlikely susceptible
L31M+Y93N28,666x>100xresistance likely
L31V+P32del>1,666,667x/cRAS/cRASresistance likely
L31V+Y93H33,666x/cRAS/cRASresistance likely>100xresistance likely986xresistance likely12328xresistance likely0.9xlikely susceptible
L31V+Y93N>100xresistance likely>100xresistance likely
P32del+Y93Hnot viable
F37L+Y93H19xlikely susceptible
Q54H+Q62E0.3x
Q54H+A92E0.9xlikely susceptible
Q54H+Y93H9.2x/cRAS/cRASresistance possible0.9xlikely susceptible
Q54H+Y93S2.7xlikely susceptible
Q54Y+Y93H67x/cRAS/cRASresistance likely1xlikely susceptible
P58A+Y93H1226xresistance likely
P58L+Y93H233xresistance likely135xresistance likely
P58S+A92T0.3xlikely susceptible
P58S+Y93H1401xresistance likely0.8xlikely susceptible
Q62E+Y93H33.3xresistance possible13.3xresistance likely
A92T+Y93H33.3xresistance possible
A92V+Y93H0.4xlikely susceptible
V121I+Y93H200xresistance likely
L28I+R30P+P32F78,000xresistance likely
L28I+R30Q+P32L34,666xresistance likely
L28M+R30L+Q54H0.3xlikely susceptible
L28M+R30Q+A92K1310666resistance likely
L28M+R30Q+A92T1.7xlikely susceptible
L28M+R30Q+Y93H1,666,667xresistance likely981xresistance likely0.5xlikely susceptible
L28M+R30Q+Y93S667xresistance likely
L28T+R30Q+Y93H41,667xresistance likely
L28V+R30Q+Y93H2,766xresistance likely
P29S+R30Q+Y93S216,333xresistance likely
R30H+P58S+Y93H6,000xresistance likely
R30Q+L31F+Y93H51,666xresistance likely
R30Q+L31M+Y93H20,333xresistance likely
R30Q+Q54H+A92K8667x/cRAS/cRASresistance likely
L31F+Q54H+Y93H6,333xresistance likely
L31F+Y93H+V121I27resistance likely
L31F+Q54F+A92E1.7xlikely susceptible
L31I+A92V+Y93H3,667xresistance likely
L31I+P58S+Y93H54,667xresistance likely
L31M+A92V+Y93H19,333xresistance likely
L31M+P58A+Y93H65000x/cRAS/cRASresistance likely
L31M+P58G+Y93H100000x/cRAS/cRASresistance likely
L31M+P58L+Y93H13,000xresistance likely
L31M+P58S+Y93H70,000xresistance likely
L31M+Q54H+A92E100xresistance possible
L31M+Q54H+Y93H4,233x/cRAS/cRASresistance likely
L31M+Q54Y+Y93H6466xresistance likely
L31V+P58A+Y93H204,000xresistance likely
L31V+P58S+Y93H140,333xresistance likely
L31V+Q54H+Y93H8,667xresistance likely
L31V+Q54H+Y93H19000x/cRAS/cRASresistance likely263xresistance likely
L31V+Q54Y+Y93H25,333xresistance likely
L31V+Q62E+Y93H67,333xresistance likely
Q54H+A92V+Y93H1xlikely susceptible
Q54H+P58A+Q62E0.7xlikely susceptible
Q54H+P58S+A92K16,333xresistance likely
Q54H+P58S+Y93H200xresistance likely
L28M+L31V+P58S+Y93N1,666,667xresistance likely
L28M+R30H+L31V+Y93H1,666,667xresistance likely
L28M+R30H+Q54H+Y93H38,333xresistance likely
L28M+R30Q+L31I+Y93H194,333xresistance likely
L28M+R30Q+L31V+Y93H557,333x/cRAS/cRASresistance likely
L28M+R30Q+Q54H+A92T0.7xlikely susceptible
R30Q+L31M+P58S+Y93H44,000xresistance likely
R30Q+L31M+Q54H+Y93H4,666xresistance likely
R30Q+L31V+P58S+Y93H76,333xresistance likely
L31IM+Q54H+Q62E+Y93H9,333x/cRAS/cRASresistance likely
L31I+Q54H+P58S+Y93H14,000xresistance likely
L31M+Q54H+A92E+Y93H113,333xresistance likely
L31M+Q54H+A92V+Y93H4,333xresistance likely
L31M+Q54H+P58S+Y93H17,667xresistance likely
L31M+Q54H+Q62E+Y93H9,333xresistance likely
L31M+Q54Y+P58S+Y93H50,000xresistance likely
L31V+Q54H+P58S+Y93H111333xresistance likely
L31V+Q54H+Q62D+Y93H31,333xresistance likely
L31V+Q54H+Q62E+Y93H31,667xresistance likely
GT1b_NS5A RAS.csv